Alli Weight Loss Studies
One of the major selling points of Alli is that there are scientific studies done on Orlistat (the active ingredient of Alli), demonstrating that using Orlistat led to weight loss by the subjects. In a one year clinical trial to evaluate the effectiveness of Orlistat in helping weight loss, over weight subjects were given 120mg of orlistat (Alli contains 60mg). The subjects were 18 or older with body mass index (BMI) between 30 and 43. Along with taking Orlistat, they also followed a calorie reduced diet. At the end of the study period, the average weight loss for the Orlistat group was 8.6kg compared to 5.5kg of the placebo group. The study also reported that the orlistat group also reduced their LDL cholesterol by 4.2%, concluding that taking orlistat with a calorie reduced diet helps with long term weight loss. They also noted that some participants reported gastro-intestinal side effects from using orlistat. [1]
In another long term, and large randomized, placebo controlled study of orlistat for weight loss, 743 subjects participated in a 2 year long trial. They participants had a BMI between 28 to 47, and followed a 600 calorie deficit per day diet for 4 weeks, and also took 120mg of orlistat for a period of one year. After one year, the subjects were reassigned either a placebo or orlistat.
The study results found that after one year, the Orlistat group lost an average 10.3kg compared to 6.1kg of the placebo group. In the second year, subjects who continued to take orlistat regained only half as much weight back as the placebo group did. The weight loss benefits of Orlistat was evident; however some subjects also reported experiencing some gastro-intestinal side effects. [2]
There are other studies showing similar types of results of using orlistat at 120mg. Alli is an over the counter diet pill containing 60mg of orlistat. Even so, the weight loss benefits of Alli should be apparent even with half dosage compared to the amount used in the clinical trials.
Alli Side Effects
As mentioned in the above studies, there are some Alli side effects - mostly related to gastro-intestinal problems. Overall, Alli diet pill is well tolerated; however, you may experience som possible gastro-intestinal side effects which can include oily stools, oily discharge, increased need to have bowel movement, difficulty controlling bowel movements, gas problems, constipation, and stomach cramps.
While diet pills such as Alli can help block fat absorption and help you lose weight as shown in the studies, it is important to point out that in all of these clinical studies, the use of orlistat was always combined with a sensible diet having a calorie deficit to help with weight loss. You simply cannot rely solely on diet pills such as Alli to help you lose weight. Along with Alli, you must ensure to have a good diet program that will help you lose weight and burn fat. Your diet must allow you to continue to lose weight or matain your weight without re-gaining what you lost after you've finished using Alli diet pills.
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Orlistat is a diet drug that helps treat obesity by preventing your body from absorbing the fat you consume from your diet, and this helps to reduce overall calorie intake since each gram of fat contains nine calories. Orlistat is marketed as Xenical which is a prescription weight loss diet pill. Alli is a less potent version of 
